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FAITS MARQUANTS

Le 23 septembre 2022, la plateforme APEX a organisé son premier Comité d'orientation scientifique et technique (COST) en présence de trois experts de renommée internationale : Catherine Georges - Présidente d'IPSEN innovation France, Roger Legrand - Directeur de l'UMR 1184 et de l'infrastructure IDMIT (Univ. Paris Saclay/Inserm/CEA) et Sylvie le Guyader - Responsable de la plateforme d'imagerie du Karolinska Institute (Suède), des tutelles Oniris (Direction) et INRAE (Centre et Département) et de deux membres invités représentant la Région Pays de la Loire et Biogenouest.

Reconduction de la labellisation IBiSA de la plateforme APEX. Participation d'APEX au premier kick-off meeting du projet H2020 FairCharm qui s'est tenu en septembre 2022 à Genève, Suisse.

1-Bertho A, Iturri L, Brisebard E, Juchaux M, Gilbert C, Ortiz R, Sebrie C, Jourdain L, Lamirault C, Ramasamy G, Pouzoulet F, Prezado Y. Evaluation of the Role of the Immune System Response After Minibeam Radiation Therapy. Int J Radiat Oncol Biol Phys. 2023 Feb 1;115(2):426-439. doi: 10.1016/j.ijrobp.2022.08.011. Epub 2022 Aug 17. PMID: 35985455.

2-Bourdon A, François V, Zhang L, Lafoux A, Fraysse B, Toumaniantz G, Larcher T, Girard T, Ledevin M, Lebreton C, Hivonnait A, Creismeas A, Allais M, Marie B, Guguin J, Blouin V, Remy S, Anegon I, Huchet C, Malerba A, Kao B, Le Heron A, Moullier P, Dickson G, Popplewell L, Adjali O, Montanaro F, Le Guiner C. Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model. Gene Ther. 2022 Sep;29(9):520-535. doi: 10.1038/s41434-022-00317-6. Epub 2022 Feb 1. PMID: 35105949.

3-Charrier M, Lorant J, Contreras-Lopez R, Téjédor G, Blanquart C, Lieubeau B, Schleder C, Leroux I, Deshayes S, Fonteneau JF, Babarit C, Hamel A, Magot A, Péréon Y, Viau S, Delorme B, Luz-Crawford P, Lamirault G, Djouad F, Rouger K. Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways. Stem Cell Res Ther. 2022 Jan 10;13(1):7. doi: 10.1186/s13287-021-02681-3. PMID: 35012660; PMCID: PMC8751303

4-De Zélicourt A, Fayssoil A, Dakouane-Giudicelli M, De Jesus I, Karoui A, Zarrouki F, Lefebvre F, Mansart A, Launay JM, Piquereau J, Tarragó MG, Bonay M, Forand A, Moog S, Piétri-Rouxel F, Brisebard E, Chini CCS, Kashyap S, Fogarty MJ, Sieck GC, Mericskay M, Chini EN, Gomez AM, Cancela JM, de la Porte S. CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype. EMBO Mol Med. 2022 May 9;14(5):e12860. doi: 10.15252/emmm.202012860. Epub 2022 Mar 17. PMID: 35298089; PMCID: PMC9081905

5-Doan Ngoc TM, Tilly G, Danger R, Bonizec O, Masset C, Guérif P, Bruneau S, Glemain A, Harb J, Cadoux M, Vivet A, Mai HL, Garcia A, Laplaud D, Liblau R, Giral M, Blandin S, Feyeux M, Dubreuil L, Pecqueur C, Cyr M, Ni W, Brouard S, Degauque N; on behalf on the DIVAT Consortium; DIVAT Consortium. Effector Memory-Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses. J Am Soc Nephrol. 2022 Dec;33(12):2211-2231. doi: 10.1681/ASN.2022030286. Epub 2022 Oct 24. PMID: 36280286; PMCID: PMC9731633

6-Dubreil L, Ledevin M, Hervet C, Menard D, Philippe C, Michel FJ, Larcher T, Meurens F, Bertho N. The Internal Conduit System of the Swine Inverted Lymph Node. Front Immunol. 2022 Jun 6;13:869384. doi: 10.3389/fimmu.2022.869384. PMID: 35734172; PMCID: PMC9207403

7-Farooq M, Simoes Eugénio M, Piquet-Pellorce C, Dion S, Raguenes-Nicol C, Santamaria K, Kara-Ali GH, Larcher T, Dimanche-Boitrel MT, Samson M, Le Seyec J. Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms. J Mol Med (Berl). 2022 Jul;100(7):1027-1038. doi: 10.1007/s00109-022-02192-5. Epub 2022 Apr 27. PMID: 35476028

8-Gougeon E, Larcher T, Ledevin M, McGrotty Y, Méheust P. Myopathy with oval inclusions in a domestic shorthair cat. JFMS Open Rep. 2022 Mar 25;8(1):20551169221081418. doi: 10.1177/20551169221081418. PMID: 35356305; PMCID: PMC8958517.

9-Lantier I, Mallet C, Souci L, Larcher T, Conradie AM, Courvoisier K, Trapp S, Pasdeloup D, Kaufer BB, Denesvre C. In vivo imaging reveals novel replication sites of a highly oncogenic avian herpesvirus in chickens. PLoS Pathog. 2022 Aug 29;18(8):e1010745. doi: 10.1371/journal.ppat.1010745. PMID: 36037230; PMCID: PMC9462805.

10-Mallet C, Souci L, Ledevin M, Georgeault S, Larcher T, Denesvre C. Establishment of a culture model for the prolonged maintenance of chicken feather follicles structure in vitro. PLoS One. 2022 Oct 7;17(10):e0271448. doi: 10.1371/journal.pone.0271448. PMID: 36206252; PMCID: PMC9544018

11-Pichon J, Ledevin M, Larcher T, Jamme F, Rouger K, Dubreil L. Label-free 3D characterization of cardiac fibrosis in muscular dystrophy using SHG imaging of cleared tissue. Biol Cell. 2022 Mar;114(3):91-103. doi: 10.1111/boc.202100056. Epub 2022 Jan 9. PMID: 34964145

12-Relizani K, Echevarría L, Zarrouki F, Gastaldi C, Dambrune C, Aupy P, Haeberli A, Komisarski M, Tensorer T, Larcher T, Svinartchouk F, Vaillend C, Garcia L, Goyenvalle A. Palmitic acid conjugation enhances potency of tricyclo-DNA splice switching oligonucleotides. Nucleic Acids Res. 2022 Jan 11;50(1):17-34. doi: 10.1093/nar/gkab1199. PMID: 34893881; PMCID: PMC8754652

13-Reynard O, Gonzalez C, Dumont C, Iampietro M, Ferren M, Le Guellec S, Laurie L, Mathieu C, Carpentier G, Roseau G, Bovier FT, Zhu Y, Le Pennec D, Montharu J, Addetia A, Greninger AL, Alabi CA, Brisebard E, Moscona A, Vecellio L, Porotto M, Horvat B. Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nat Commun. 2022 Oct 28;13(1):6439. doi: 10.1038/s41467-022-33832-6. PMID: 36307480; PMCID: PMC9616412.